Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

DOI Web Site 被引用文献24件
  • Alain B. Schreiber
    Institute of Biological Sciences, Syntex Research, Palo Alto, CA 94304.
  • Marjorie E. Winkler
    Department of Protein Biochemistry, Genentech, Inc., South San Francisco, CA 94080.
  • Rik Derynck
    Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080.

抄録

<jats:p> Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are structurally related peptides. Purified human TGF-α produced in <jats:italic>Escherichia coli</jats:italic> and pure natural mouse EGF were compared for their ability to bind to target cells in vitro and to promote angiogenesis in the hamster cheek pouch bioassay. Both polypeptides were found to bind in vitro to several target cells, including endothelial cells, and to stimulate their DNA synthesis in an equipotent fashion. In vivo, however, TGF-α was more potent than EGF in promoting angiogenesis and, because TGF-α is known to be secreted by a variety of human tumors, it is suggested that this growth factor may contribute to tumor-induced angiogenesis. </jats:p>

収録刊行物

  • Science

    Science 232 (4755), 1250-1253, 1986-06-06

    American Association for the Advancement of Science (AAAS)

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