A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes

DOI Web Site 被引用文献7件
  • J. H. Pate Skene
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305.
  • Richard D. Jacobson
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305.
  • G. Jackson Snipes
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232.
  • C. Brian McGuire
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232.
  • Jeanette J. Norden
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232.
  • John A. Freeman
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232.

抄録

<jats:p>Growth cones are specialized structures that form the distal tips of growing axons. During both normal development of the nervous system and regeneration of injured nerves, growth cones are essential for elongation and guidance of growing axons. Developmental and regenerative axon growth is frequently accompanied by elevated synthesis of a protein designated GAP-43. GAP-43 has now been found to be a major component of growth-cone membranes in developing rat brains. Relative to total protein, GAP-43 is approximately 12 times as abundant in growth-cone membranes as in synaptic membranes from adult brains. Immunohistochemical localization of GAP-43 in frozen sections of developing brain indicates that the protein is specifically associated with neuropil areas containing growth cones and immature synaptic terminals. The results support the proposal that GAP-43 plays a role in axon growth.</jats:p>

収録刊行物

  • Science

    Science 233 (4765), 783-786, 1986-08-15

    American Association for the Advancement of Science (AAAS)

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