Inhibitory Action of an Imidazole Compound on Ecdysone Synthesis in Prothoracic Glands of the Silkworm, <i>Bombyx mori</i>

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  • (imidazole compound/ecdysteroids/prothoracic gland/precocious pupation/<i>Bombyx mori</i>)

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<jats:p>The precocious pupation was induced either by allatectomy at the time of third ecdysis or by topical application of an imidazole compound (KK‐42; 1‐benzyl‐5‐[(<jats:italic>E</jats:italic>)‐2, 6‐dimethyl‐1, 5‐heptadienyl] imidazole) to the fourth (penultimate) instar larvae of the silkworm, <jats:italic>Bombyx mori.</jats:italic> However, the critical period for KK‐42 treatment in induction of precocious pupation was longer than that for allatectomy. The effects of KK‐42 depended on the doses applied and a half‐maximum dose was estimated to be approx. 10 μg/larva. KK‐42 suppressed the increase in hemolymph ecdysteroid titres leading to larval ecdysis in controls. Ecdysteroid levels remained at low levels for about 6 days after the treatment, followed by an increase toward precocious pupation. When the prothoracic glands from the mature fifth instar larvac were incubated <jats:italic>in vitro</jats:italic> in Grace's medium containing various concentrations of KK‐42, secretion of ecdysone into the medium was suppressed depending upon the doses of KK‐42 added and a half‐inhibition concentration was estimated to be approx. 1 nM. Thus, KK‐42 was shown to be an inhibitory agent to ecdysteroid secretion in silkworm larvae.</jats:p>

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