The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

• Anthony S. Fauci

  National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

抄録

Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.

収録刊行物

• Science

  Science 239 (4840), 617-622, 1988-02-05

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361137044230013568
• NII論文ID: 80003789111
• DOI: 10.1126/science.3277274
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.3277274
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