Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

DOI Web Site 被引用文献38件
  • Thomas Sutula
    Departments of Neurology and Anatomy and the Neurosciences Training Program, University of Wisconsin, Madison, WI 53792.
  • Xiao-Xian He
    Departments of Neurology and Anatomy and the Neurosciences Training Program, University of Wisconsin, Madison, WI 53792.
  • Jose Cavazos
    Departments of Neurology and Anatomy and the Neurosciences Training Program, University of Wisconsin, Madison, WI 53792.
  • Grayson Scott
    Departments of Neurology and Anatomy and the Neurosciences Training Program, University of Wisconsin, Madison, WI 53792.

抄録

<jats:p>Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.</jats:p>

収録刊行物

  • Science

    Science 239 (4844), 1147-1150, 1988-03-04

    American Association for the Advancement of Science (AAAS)

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