Expression of c- <i>fos</i> Protein in Brain: Metabolic Mapping at the Cellular Level

DOI Web Site 被引用文献74件
  • S. M. Sagar
    Department of Neurology, University of California, and Neurology Service, Veterans Administration (VA) Medical Center, San Francisco, CA 94121.
  • F. R. Sharp
    Departments of Neurology and Physiology, University of California, and Neurology Service, VA Medical Center, San Francisco, CA 94121.
  • T. Curran
    Department of Molecular Oncology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.

抄録

<jats:p> The proto-oncogene c- <jats:italic>fos</jats:italic> is expressed in neurons in response to direct stimulation by growth factors and neurotransmitters. In order to determine whether the c- <jats:italic>fos</jats:italic> protein (Fos) and Fos-related proteins can be induced in response to polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically and Fos expression examined immunohistochemically. Three hours after the onset of stimulation, focal nuclear Fos staining was seen in motor and sensory thalamus, pontine nuclei, globus pallidus, and cerebellum. Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei. Fos immunohistochemistry therefore provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways. </jats:p>

収録刊行物

  • Science

    Science 240 (4857), 1328-1331, 1988-06-03

    American Association for the Advancement of Science (AAAS)

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