A Bitter Substance Induces a Rise in Intracellular Calcium in a Subpopulation of Rat Taste Cells

DOI Web Site 被引用文献25件
  • Myles H. Akabas
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Jane Dodd
    Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Qais Al-Awqati
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

抄録

<jats:p>The sense of taste permits animals to discriminate between foods that are safe and those that are toxic. Because most poisonous plant alkaloids are intensely bitter, bitter taste warns animals of potentially hazardous foods. To investigate the mechanism of bitter taste transduction, a preparation of dissociated rat taste cells was developed that can be studied with techniques designed for single-cell measurements. Denatonium, a very bitter substance, caused a rise in the intracellular calcium concentration due to release from internal stores in a small subpopulation of taste cells. Thus, the transduction of bitter taste may occur via a receptor-second messenger mechanism leading to neurotransmitter release and may not involve depolarization-mediated calcium entry.</jats:p>

収録刊行物

  • Science

    Science 242 (4881), 1047-1050, 1988-11-18

    American Association for the Advancement of Science (AAAS)

被引用文献 (25)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ