A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
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- J Lisman
- Department of Biology, Brandeis University, Waltham, MA 02254.
抄録
<jats:p>In a previous paper, a model was presented showing how the group of Ca2+/calmodulin-dependent protein kinase II molecules contained within a postsynaptic density could stably store a graded synaptic weight. This paper completes the model by showing how bidirectional control of synaptic weight could be achieved. It is proposed that the quantitative level of the activity-dependent rise in postsynaptic Ca2+ determines whether the synaptic weight will increase or decrease. It is further proposed that reduction of synaptic weight is governed by protein phosphatase 1, an enzyme indirectly controlled by Ca2+ through reactions involving phosphatase inhibitor 1, cAMP-dependent protein kinase, calcineurin, and adenylate cyclase. Modeling of this biochemical system shows that it can function as an analog computer that can store a synaptic weight and modify it in accord with the Hebb and anti-Hebb learning rules.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 86 (23), 9574-9578, 1989-12
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1360292621617971968
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- NII論文ID
- 80004919641
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- ISSN
- 10916490
- 00278424
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- データソース種別
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