The Staphylococcal Enterotoxins and Their Relatives

DOI Web Site 被引用文献62件
  • P Marrack
    Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, and Departments of Biochemistry, Microbiology, and Immunology, and Medicine, University of Colorado Health Sciences Center, Denver, CO.
  • J Kappler
    Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, and Departments of Biochemistry, Microbiology, and Immunology, and Medicine, University of Colorado Health Sciences Center, Denver, CO.

抄録

<jats:p> Staphylococcal enterotoxins and a group of related proteins made by <jats:italic>Streptococci</jats:italic> cause food poisoning and shock in man and animals. These proteins share an ability to bind to human and mouse major histocompatibility complex proteins. The complex ligand so formed has specificity for a particular part of T cell receptors, V <jats:sub>β</jats:sub> , and by engaging V <jats:sub>β</jats:sub> can stimulate many T cells. It is likely that some or all of the pathological effects of these toxins are caused by their ability to activate quickly so many T cells. It is also possible that encounters with such toxins have caused mice, at least, to evolve mechanisms for varying their T cell V <jats:sub>β</jats:sub> repertoires, such that they are less susceptible to attack by the toxins. </jats:p>

収録刊行物

  • Science

    Science 248 (4956), 705-711, 1990-05-11

    American Association for the Advancement of Science (AAAS)

被引用文献 (62)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ