冠動脈硬化症における脂肪負荷後のリポ蛋白代謝の検討

• 池脇 克則

  防衛医科大学校第一内科

書誌事項

タイトル別名

• Postprandial Lipemia in Patients with Coronary Artery Disease

抄録

To elucidate the atherogenecity of postprandial lipemia, 15 angiographically defined normolipidemic patients with coronary artery disease (CAD) and 15 normolipidemic healthy controls were recruited for a fat loading test. After administering cream (40g/m²) and Vitamin A (50, 000IU/m²), we monitered the plasma TG, Vitamin A and remnant-like particles (RLP), detected by anti-apo Al and anti-apo B monoclonal antibodies bound-mixed gel, for up to 12 hours.<br>In the CAD group, the TG increased more slowly than in the controls. There was a striking difference in the RLP-C between the two groups. In a fasting state, the RLP positive rate was 20% in the CAD group and 0% in control group (not significant).<br>In a postprandial state, however, the RLP positive rate was 93% and 20%, respectively (p<0.001). The ratio of the RLP-C/RLP-TG was higher in CAD group, suggesting that RLP contained atherogenic lipoproteins which were rich in cholesterol such as chylomicron remnants and β-VLDL.<br>A multivariate analysis revealed that RLP was the strongest (predictive) factor for predicting the CAD. The data obtained indicated that the subjects with imparied postprandial lipemia might be susceptible to CAD.

収録刊行物

• The Journal of Japan Atherosclerosis Society

  The Journal of Japan Atherosclerosis Society 18 (9-10), 887-895, 1990

  一般社団法人 日本動脈硬化学会

キーワード

• Coronary artery disease
• Postprandial Lipemia
• Fat-loading test
• Chylomicron
• Remnant-like particles

詳細情報

• CRID: 1390282679670475520
• NII論文ID: 130006853862
• NII論文ID: 80005470070
• DOI: 10.5551/jat1973.18.9-10_887
• ISSN: 21858284
• ISSN: 03862682
• Web Site: https://www.jstage.jst.go.jp/article/jat1973/18/9-10/18_9-10_887/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1992015034
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