ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le ^x

• M. Laurie Phillips

  Cytel Corp., La Jolla, CA 92037.

• Edward Nudelman

  Biomembrane Institute, Seattle, WA 98119.

• Federico C. A. Gaeta

  Cytel Corp., La Jolla, CA 92037.

• Mary Perez

  Cytel Corp., La Jolla, CA 92037.

• Anil K. Singhal

  Biomembrane Institute, Seattle, WA 98119.

• Sen-Itiroh Hakomori

  Biomembrane Institute, Seattle, WA 98119.

• James C. Paulson

  Cytel Corp., La Jolla, CA 92037.

抄録

Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLe x ; NeuAcα2,3Galβ 1,4(Fucα1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.

収録刊行物

• Science

  Science 250 (4984), 1130-1132, 1990-11-23

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361699993521113088
• NII論文ID: 80005612146
• DOI: 10.1126/science.1701274
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1701274
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  • CiNii Articles