An epidemic of hepatitis A at an institution for the mentally retarded in Yamagata Prefecture. Time course of anti-HAV IgM antibody, clinical significance of anti-HAV IgA antibody test and prevention against hepatitis A with immunoglobulin.

• SHINZAWA Haruhide

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• TOGASHI Hitoshi

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• WAKABAYASHI Hiroto

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• YAMADA Nobuo

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• HUANG Yong

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• TAKAHASHI Tsuneo

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• ISHIKAWA Makoto

  Second Department of Internal Medicine, School of Medicine, Yamagata University

• MIURA Hideto

  Department of Clinical Labolatory, School of Medicine, Yamagata University

• MIYAZAWA Kozui

  Department of Clinical Labolatory, School of Medicine, Yamagata University

• IINO Shirou

  First Department of Internal Medicine, School of Medicine, Tokyo University

• LI Chenming

  National Institute of Health

• MORISTUGU Yasuo

  National Institute of Health

Bibliographic Information

Other Title

• 山形県の精神薄弱者施設に流行したＡ型肝炎　流行の実態，ＩｇＭ型　抗ＨＡＶ抗体の消長，ＩｇＡ型　抗ＨＡＶ抗体検出の臨床的意義および免疫グロブリンによる予防について
• Time course of anti-HAV IgM antibody, clinical significance of anti-HAV IgA antibody test and prevention against hepatitis A with immunoglobulin
• 流行の実態,IgM型抗HAV抗体の消長,IgA型抗HAV抗体検出の臨床的意義および免疫グロブリンによる予防について

Abstract

An epidemic of hepatitis A, seemingly via transmission of virus by contact, occurred an institution for the mentally retarded (aged over 18 years) from January 1988 to April of the same year. At this institution, 43 retarded residents and 15 staff members were infected with hepatitis A virus (HAV). Most were living or working in the dormitory accomodating persons with the lowest IQ (intelligence quotient). The incidence of infection among the retarded was as high as 69%, and was particularly high in persons aged between 30 and 40 years. In retarded males, 67 days were required, on average, for normalization of disturbed liver function. In the early stage after onset of hepatitis A, anti-HA IgM antibody (IgMHA) was negative in 21 cases in spite of abnormalities in liver function. This findings indicates the necessity of repeated IgMHA tests in individuals with abnormal liver function during hepatitis A epidemics. In as many as 15 cases, IgMHA remained positive for a relatively long period (6 months). Anti-HA IgA antibody (IgAHA) was positive in all IgMHA positive cases and 33 persons related to the dormitories where the epidemic occurred. This result indicates that IgAHA testing is useful for estimating the scale of HAV infection. Human immunoglobulin therapy seems to be effective in preventing further spread of HAV infection and in relieving symptoms if done in the preclinical stage.

Journal

• Kanzo

  Kanzo 31 (12), 1371-1379, 1990

  The Japan Society of Hepatology

Keywords

• A型肝炎
• 流行性肝炎
• IgM型HA抗体
• IgA型HA抗体
• 人免疫グロブリン

Details

• CRID: 1390001204791562496
• NII Article ID: 130000878475
• NII Article ID: 80005660033
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.31.1371
• ISSN: 18813593
• ISSN: 04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo1960/31/12/31_12_1371/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1991159428
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed