The <i>myoD</i> Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

• Harold Weintraub

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Robert Davis

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Stephen Tapscott

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Matthew Thayer

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Michael Krause

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Robert Benezra

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• T. Keith Blackwell

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• David Turner

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Ralph Rupp

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Stanley Hollenberg

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Yuan Zhuang

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

• Andrew Lassar

  Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

抄録

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

収録刊行物

• Science

  Science 251 (4995), 761-766, 1991-02-15

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418519302547200
• NII論文ID: 80005759831
• DOI: 10.1126/science.1846704
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1846704
• データソース種別:
  • Crossref
  • CiNii Articles