African Populations and the Evolution of Human Mitochondrial DNA

DOI Web Site 被引用文献23件
  • Linda Vigilant
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720.
  • Mark Stoneking
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720.
  • Henry Harpending
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802
  • Kristen Hawkes
    Department of Anthropology, University of Utah, Salt Lake City, UT 84112
  • Allan C. Wilson
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720.

抄録

<jats:p>The proposal that all mitochondrial DNA (mtDNA) types in contemporary humans stem from a common ancestor present in an African population some 200,000 years ago has attracted much attention. To study this proposal further, two hypervariable segments of mtDNA were sequenced from 189 people of diverse geographic origin, including 121 native Africans. Geographic specificity was observed in that identical mtDNA types are shared within but not between populations. A tree relating these mtDNA sequences to one another and to a chimpanzee sequence has many deep branches leading exclusively to African mtDNAs. An African origin for human mtDNA is supported by two statistical tests. With the use of the chimpanzee and human sequences to calibrate the rate of mtDNA evolution, the age of the common human mtDNA ancestor is placed between 166,000 and 249,000 years. These results thus support and extend the African origin hypothesis of human mtDNA evolution.</jats:p>

収録刊行物

  • Science

    Science 253 (5027), 1503-1507, 1991-09-27

    American Association for the Advancement of Science (AAAS)

被引用文献 (23)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ