インスリン非依存性糖尿病に合併した高脂血症に対する大柴胡湯・プロブコールの併用投与のリポ蛋白脂質代謝に与える影響

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  • The Effect of Oriental Medicine (Dai-Sai-Ko-Tou) with Probucol on Lipoprotein Metabolism in Non-Insulin Dependent Diabetics with Hypercholesterolemia

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Probucol (P) is known to decrease plasma HDL-chol as well as the total cholesterol (TC) level. Dai-Sai-Ko-Tou (D), a traditional oriental medicine, which has been used to treat obesity, has recently been reported to raise plasma HDL-chol levels in animals. Our aim was to examine the effect of the administration of P together with D on lipoprotein metabolism. Twenty six Noninsulin diabetics with hypercholesterolemia were treated either with P only (Single-treated group: S group) or with P and D (Combined-treated group: C group) for 3 months. Both treatments decreased the TC, LDL-chol, Apo A-I and Apo B levels significantly. VLDL-chol (64±32→50±24mg/dl mean±S.D.) and Apo E (12±4→10±4) were also decreased significantly only in the C group. HDL-chol in the C group marginally increased, while that in the S group decreased. The ΔHDL-chol in each group (6±21 vs. -12±20) was significantly different. In the S group ΔHDL-chol was negatively correlated with ΔVLDL-chol (r=-0.86, p<0.001) or positively correlated with ΔApo E(r=0.61, p<0.05). But these findings were not found in the D group. The ΔApo A-I was diminished in the C group (-20±21 vs. -38±21, p<0.05). In conclusion, the addition of Dai-Sai-Ko-Tou to Probucol resulted in an increase in plasma HDL-chol, possibly through the suppression of the HDL-VLDL pathway, and decreased the degree of inhibition of HDL synthesis.

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