Optical Coherence Tomography

DOI Web Site 被引用文献474件
  • David Huang
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics,, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Eric A. Swanson
    Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02139.
  • Charles P. Lin
    Department of Ophthalmology, Harvard Medical School and the Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114.
  • Joel S. Schuman
    Department of Ophthalmology, Harvard Medical School and the Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114.
  • William G. Stinson
    Department of Ophthalmology, Harvard Medical School and the Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114.
  • Warren Chang
    Department of Ophthalmology, Harvard Medical School and the Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114.
  • Michael R. Hee
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics,, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Thomas Flotte
    Wellman Laboratories, Massachusetts General Hospital, Boston, MA 02114.
  • Kenton Gregory
    Wellman Laboratories, Massachusetts General Hospital, Boston, MA 02114.
  • Carmen A. Puliafito
    Department of Ophthalmology, Harvard Medical School and the Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114.
  • James G. Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics,, Massachusetts Institute of Technology, Cambridge, MA 02139.

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<jats:p> A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as ∼10 <jats:sup>-10</jats:sup> of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively. </jats:p>

収録刊行物

  • Science

    Science 254 (5035), 1178-1181, 1991-11-22

    American Association for the Advancement of Science (AAAS)

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