書誌事項
- タイトル別名
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- Relationship between virulence to mice and macrophage chemiluminescence-triggering activity of the Mycobacterium avium complex belonging to various serovars.
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抄録
Macrophage chemiluminescence (MφCL)-triggering activities of Mycobacterium avium complex (MAC) strains belonging to various serovars were examined. When SmT colonial variant (smooth, transparent, irregularly shaped) of M. intracellulare N-260 strain was compared with its SmD variant (smooth, opaque, dome-shaped) for Mφ CL-triggering function and resistance to antimicrobial activity of murine resident peritoneal Mcbs, the SmT variant showed much lower Mφ CL-triggering activity accompanied by its high resistance to Mφ microbicidal functions. Thus, difference in the virulence of the two MAC clolonial variants seems to be originated from their different activities in Mφ-triggering to be stimulated state in terms of O2-dependent antimicrobial functions.<BR>When disease-associated MAC strains belonging to serovars 1, 14, 16 (major serovars seen in Japan), 8 (intermediate serovar) and 9 (minor serovar) were challenged to mice, their virulence, in terms of mortality of host animals and growth of the organisms in the lungs, was nearly in the order of serovar 16, 14, 8, 1 and 9. However, there was found no obvious serovar-dependent difference in Mφ CL-triggering activity of these MAC strains. Thus, no significant correlation was found between virulence of the MAC strains of various serovars and their triggering activities for Mφ active oxygen production, which is important for the O2-dependent microbicidal mechanisms of host Mφs.<BR>When M. avium and M. intracellulare from human or environmental sources were examined for virulence to mice in terms of incidence and degree of gross pulmonary lesions or behavior of the organisms in the lungs, human-derived M. intracellulare caused most progressed state of gross lung lesions in all test mice, with average 2.6 Log-increase in bacterial CFU in the lungs. This was followed by environmental M. intracellulare, which caused less degree of lesions in 15 of 19 mice and 1.3Log-increase in pulmonary CFU. On the other hand, human-derived M. avium caused much weaker lesions in a small part of test animals and environmental M. avium caused no lesions. In the case of the M. aviuminfection, there was substantially no bacterial growth in the host lungs. These results indicate that the virulence of the MAC was in the order of human-derived M. intracellulare, enviromental M. intracellulare, human-derived M. avium and environmental M. avium. On the contrary, there was found no obvious difference in Mφ CL-triggering activity among these MAC species from the two types of sources.<BR>Thus, at least among SmT variants of the MAC, there seems to be no relationship between their activity to induced MO respiratory burst and virulence to mice. Therefore, it is thought that O2-dependent antimicrobial mechanism in host Mφs plays only minor roles in the host resistance to the SmT colonial variants of the MAC.
収録刊行物
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- 結核
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結核 67 (1), 1-8, 1992
一般社団法人 日本結核病学会