Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

• Robert L. Jilka

• Giao Hangoc

• Giuseppe Girasole

• Giovanni Passeri

• Daniel C. Williams

• John S. Abrams

• Brendan Boyce

• Hal Broxmeyer

• Stavros C. Manolagas

Abstract

Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17β-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17β-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.

Journal

• Science

  Science 257 (5066), 88-91, 1992-07-03

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1360574095321530112
• NII Article ID: 80006586243
• DOI: 10.1126/science.1621100
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1621100
• Data Source:
  • Crossref
  • CiNii Articles