Actin Filament Dynamics in Living Glial Cells Imaged by Atomic Force Microscopy

DOI Web Site 被引用文献46件
  • E. Henderson
    Department of Zoology and Genetics, Signal Transduction Training Group, Iowa State University, Ames, IA 5001 1.
  • P. G. Haydon
    Department of Zoology and Genetics, Signal Transduction Training Group, Iowa State University, Ames, IA 5001 1.
  • D. S. Sakaguchi
    Department of Zoology and Genetics, Signal Transduction Training Group, Iowa State University, Ames, IA 5001 1.

抄録

<jats:p>Observation of filamentous actin (F-actin) in living cells is currently limited to the resolution of the light microscope. Higher resolution procedures require sample fixation and preclude dynamic studies. The atomic force microscope (AFM) can image and manipulate samples at very high, sometimes atomic resolution by scanning a fine tip over the surface of interest and detecting physical interactions between the tip and sample. This study demonstrates that F-actin can be readily resolved in living cells with the AFM and that the dynamic properties of F-actin are easily observed.</jats:p>

収録刊行物

  • Science

    Science 257 (5078), 1944-1946, 1992-09-25

    American Association for the Advancement of Science (AAAS)

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