Tumor Rejection After Direct Costimulation of CD8 <sup>+</sup> T Cells by B7-Transfected Melanoma Cells

DOI Web Site 被引用文献14件
  • Sarah E. Townsend
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720.
  • James P. Allison
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720.

抄録

<jats:p> A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8 <jats:sup>+</jats:sup> T cells; CD4 <jats:sup>+</jats:sup> T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo. </jats:p>

収録刊行物

  • Science

    Science 259 (5093), 368-370, 1993-01-15

    American Association for the Advancement of Science (AAAS)

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