Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

DOI Web Site 被引用文献59件
  • Jianhua Cheng
    University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA.
  • Tong Zhou
    University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA.
  • Changdan Liu
    University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA.
  • John P. Shapiro
    LXR Biotechnology Inc., Richmond, CA 94804, USA.
  • Matthew J. Brauer
    LXR Biotechnology Inc., Richmond, CA 94804, USA.
  • Michael C. Kiefer
    LXR Biotechnology Inc., Richmond, CA 94804, USA.
  • Philip J. Barr
    LXR Biotechnology Inc., Richmond, CA 94804, USA.
  • John D. Mountz
    University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA.

抄録

<jats:p>Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types. Molecular cloning and nucleotide sequence analysis revealed a human Fas messenger RNA variant capable of encoding a soluble Fas molecule lacking the transmembrane domain because of the deletion of an exon encoding this region. The expression of soluble Fas was confirmed by flow cytometry and immunocytochemical analysis. Supernatants from cells transfected with the variant messenger RNA blocked apoptosis induced by the antibody to Fas. Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features.</jats:p>

収録刊行物

  • Science

    Science 263 (5154), 1759-1762, 1994-03-25

    American Association for the Advancement of Science (AAAS)

被引用文献 (59)*注記

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