Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
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- I F Charo
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
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- S J Myers
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
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- A Herman
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
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- C Franci
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
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- A J Connolly
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
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- S R Coughlin
- Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100.
抄録
<jats:p>Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of cytokines that mediate leukocyte chemotaxis. The potent and specific activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory diseases. We have isolated cDNAs that encode two MCP-1-specific receptors with alternatively spliced carboxyl tails. Expression of the receptors in Xenopus oocytes conferred robust mobilization of intracellular calcium in response to nanomolar concentrations of MCP-1 but not to related chemokines. The MCP-1 receptors are most closely related to the receptor for the chemokines macrophage inflammatory protein 1 alpha and RANTES (regulated on activation, normal T expressed and secreted). The identification of the MCP-1 receptor and cloning of two distinct isoforms provide powerful tools for understanding the specificity and signaling mechanisms of this important chemokine.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 91 (7), 2752-2756, 1994-03-29
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1362825895165438848
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- NII論文ID
- 80007565361
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- ISSN
- 10916490
- 00278424
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- データソース種別
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