BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.

DOI Web Site 被引用文献23件
  • T Kaisho
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • J Ishikawa
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • K Oritani
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • J Inazawa
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • H Tomizawa
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • O Muraoka
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • T Ochi
    Division of Molecular Oncology, Osaka University Medical School, Japan.
  • T Hirano
    Division of Molecular Oncology, Osaka University Medical School, Japan.

抄録

<jats:p>Bone marrow stromal cells are essential for B-lymphocyte development. However, how stromal cells regulate B lymphopoiesis is not clear. In this paper, we report the molecular cloning of a stromal cell line-derived glycosyl-phosphatidylinositol-anchored molecule, BST-1, that facilitates pre-B-cell growth. The deduced amino acid sequence of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a wide range of tissues and in umbilical vein endothelial cells, whereas it was scarcely expressed in a variety of hematopoietic cell lines. The gene for BST-1 was assigned to chromosome 14q32.3, where immunoglobulin heavy-chain genes are clustered. BST-1 expression was enhanced in rheumatoid arthritis patient-derived bone marrow stromal cell lines that were previously shown to have an enhanced ability to support the growth of a pre-B-cell line as compared with stromal cell lines derived from healthy donors.</jats:p>

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