慢性副鼻腔炎へのロキシスロマイシン療法　単独投与の有効性と作用機序について

DOI 被引用文献12件

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  • Roxithromycin for Chronic Sinusitis. A Study of Its Efficacy and Mechanism of Action.
  • - A Study of Its Efficacy and Mechanism of Action -
  • ―単独投与の有効性と作用機序について―

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In a clinical trial of the efficacy of roxithromycin (RXM) 150mg was administered twice a day to patients with chronic sinusitis. Subjective improvement was noted in 72.4%, and objective improvement was confirmed in 65.5% by endonasal findings and in 44.8% by X-ray findings after treatment with RXM for 8 to 12 weeks. One patient complained of epigastric pain, but it was mild. The administration of RXM did not affect the nasal bacterial flora.<br>An in vitro study showed that RXM significantly suppressed the production of TNF-a by tonsillar cells stimulated with PHA, LPS or RSV. RXM also blocked the disturbance of ciliary activity in nasal epithelial cells induced by the administration of TNF-a. RXM may control inflammation by suppressing the production of and blocking the adverse effects of certain regulatory cytokines.

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