MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

DOI Web Site 被引用文献30件
  • H. J. Fehling
    Basel Institute for Immunology, CH-4058 Basel, Switzerland.
  • W. Swat
    Basel Institute for Immunology, CH-4058 Basel, Switzerland.
  • C. Laplace
    Basel Institute for Immunology, CH-4058 Basel, Switzerland.
  • R. Kühn
    Institute for Genetics, University of Cologne, D-50931 Cologne, Germany.
  • K. Rajewsky
    Institute for Genetics, University of Cologne, D-50931 Cologne, Germany.
  • U. Müller
    Basel Institute for Immunology, CH-4058 Basel, Switzerland.
  • H. von Boehmer
    Basel Institute for Immunology, CH-4058 Basel, Switzerland.

抄録

<jats:p>Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.</jats:p>

収録刊行物

  • Science

    Science 265 (5176), 1234-1237, 1994-08-26

    American Association for the Advancement of Science (AAAS)

被引用文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ