Notch Signaling

• Spyros Artavanis-Tsakonas

  Howard Hughes Medical Institute and Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, CT 06536, USA.

• Kenji Matsuno

  Howard Hughes Medical Institute and Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, CT 06536, USA.

• Mark E. Fortini

  Howard Hughes Medical Institute and Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, CT 06536, USA.

抄録

The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins in a general mechanism of local cell signaling, which includes interactions between equivalent cells and between different cell types. Genetic approaches in flies and worms have identified putative components of the signaling cascade, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain. One factor, the Drosophila Suppressor of Hairless protein, is a DNA-binding protein, which suggests that Notch signaling may involve relatively direct signal transmission from the cell surface to the nucleus. Several vertebrate Notch receptors have also been discovered recently and play important roles in normal development and tumorigenesis.

収録刊行物

• Science

  Science 268 (5208), 225-232, 1995-04-14

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362544419156552960
• NII論文ID: 80008269983
• DOI: 10.1126/science.7716513
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.7716513
• データソース種別:
  • Crossref
  • CiNii Articles