Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

• T R Golub

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• G F Barker

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• S K Bohlander

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• S W Hiebert

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• D C Ward

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• P Bray-Ward

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• E Morgan

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• S C Raimondi

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• J D Rowley

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

• D G Gilliland

  Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA, USA.

抄録

Chromosomal rearrangements involving band 12p13 are found in a wide variety of human leukemias but are particularly common in childhood acute lymphoblastic leukemia. The genes involved in these rearrangements, however, have not been identified. We now report the cloning of a t(12;21) translocation breakpoint involving 12p13 and 21q22 in two cases of childhood pre-B acute lymphoblastic leukemia, in which t(12;21) rearrangements were not initially apparent. The consequence of the translocation is fusion of the helix-loop-helix domain of TEL, an ETS-like putative transcription factor, to the DNA-binding and transactivation domains of the transcription factor AML1. These data show that TEL, previously shown to be fused to the platelet-derived growth factor receptor beta in chronic myelomonocytic leukemia, can be implicated in the pathogenesis of leukemia through its fusion to either a receptor tyrosine kinase or a transcription factor. The TEL-AML1 fusion also indicates that translocations affecting the AML1 gene can be associated with lymphoid, as well as myeloid, malignancy.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 92 (11), 4917-4921, 1995-05-23

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363670318445023488
• NII論文ID: 80008346764
• DOI: 10.1073/pnas.92.11.4917
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.92.11.4917
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