Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

• B L Rosenzweig

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• T Imamura

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• T Okadome

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• G N Cox

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• H Yamashita

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• P ten Dijke

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• C H Heldin

  Synergen, Inc., Boulder, CO 80301-2546, USA.

• K Miyazono

  Synergen, Inc., Boulder, CO 80301-2546, USA.

抄録

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily. Several members of this family have been shown to transduce their signals through binding to type I and type II serine-(threonine) kinase receptors. Here we report the cDNA cloning and characterization of a human type II receptor for BMPs (BMPR-II), which is distantly related to DAF-4, a BMP type II receptor from Caenorhabditis elegans. In transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to BMPR-II. BMPR-II bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type I receptors for BMPs. Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 92 (17), 7632-7636, 1995-08-15

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363951796127850752
• NII論文ID: 80008502007
• DOI: 10.1073/pnas.92.17.7632
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.92.17.7632
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