The Minimal Gene Complement of <i>Mycoplasma genitalium</i>

DOI Web Site 被引用文献74件
  • Claire M. Fraser
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jeannine D. Gocayne
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Owen White
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Mark D. Adams
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Rebecca A. Clayton
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Robert D. Fleischmann
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Carol J. Bult
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Anthony R. Kerlavage
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Granger Sutton
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jenny M. Kelley
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Janice L. Fritchman
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Janice F. Weidman
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Keith V. Small
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Mina Sandusky
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Joyce Fuhrmann
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • David Nguyen
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Teresa R. Utterback
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Deborah M. Saudek
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Cheryl A. Phillips
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Joseph M. Merrick
    J. M. Merrick is in the Department of Microbiology, State University of New York at Buffalo, Buffalo, NY 14214, USA.
  • Jean-Francois Tomb
    J.-F. Tomb, B. A. Dougherty and H. O. Smith are at the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Brian A. Dougherty
    J.-F. Tomb, B. A. Dougherty and H. O. Smith are at the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Kenneth F. Bott
    K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
  • Ping-Chuan Hu
    K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
  • Thomas S. Lucier
    K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
  • Scott N. Peterson
    K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
  • Hamilton O. Smith
    J.-F. Tomb, B. A. Dougherty and H. O. Smith are at the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Clyde A. Hutchison
    K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
  • J. Craig Venter
    C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

抄録

<jats:p> The complete nucleotide sequence (580,070 base pairs) of the <jats:italic>Mycoplasma genitalium</jats:italic> genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of <jats:italic>Haemophilus influenzae</jats:italic> suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms. </jats:p>

収録刊行物

  • Science

    Science 270 (5235), 397-404, 1995-10-20

    American Association for the Advancement of Science (AAAS)

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