The Cytolytic P <sub>2Z</sub> Receptor for Extracellular ATP Identified as a P <sub>2X</sub> Receptor (P2X <sub>7</sub> )

DOI Web Site 被引用文献64件
  • A. Surprenant
    Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.
  • F. Rassendren
    Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.
  • E. Kawashima
    Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.
  • R. A. North
    Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.
  • G. Buell
    Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.

抄録

<jats:p> The P <jats:sub>2Z</jats:sub> receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P <jats:sub>2X</jats:sub> receptors, are permeable only to small cations. Here, an ATP receptor, the P2X <jats:sub>7</jats:sub> receptor, was cloned from rat brain and exhibited both these properties. This protein is homologous to other P <jats:sub>2X</jats:sub> receptors but has a unique carboxyl-terminal domain that was required for the lytic actions of ATP. Thus, the P2X <jats:sub>7</jats:sub> (or P <jats:sub>2Z</jats:sub> ) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. </jats:p>

収録刊行物

  • Science

    Science 272 (5262), 735-738, 1996-05-03

    American Association for the Advancement of Science (AAAS)

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