Determination of Life-Span in <b> <i>Caenorhabditis elegans</i> </b> by Four Clock Genes

DOI Web Site 被引用文献13件
  • Bernard Lakowski
    Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montréal, Québec, Canada H3A 1B1.
  • Siegfried Hekimi
    Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montréal, Québec, Canada H3A 1B1.

抄録

<jats:p> The nematode worm <jats:italic>Caenorhabditis elegans</jats:italic> is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes— <jats:italic>clk-1, clk-2</jats:italic> , <jats:italic>clk-3,</jats:italic> and <jats:italic>gro-1</jats:italic> — interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer formation (an alternative larval stage induced by adverse conditions in which development is arrested) can also extend life-span, but the life extension of Clock mutants appears to be independent of these genes. The <jats:italic>daf-2(e1370) clk-1(e2519)</jats:italic> worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms. </jats:p>

収録刊行物

  • Science

    Science 272 (5264), 1010-1013, 1996-05-17

    American Association for the Advancement of Science (AAAS)

被引用文献 (13)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ