PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

DOI Web Site 被引用文献85件
  • Beate Lanske
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Andrew C. Karaplis
    A. C. Karaplis, Department of Medicine, Sir Mortimer B. Davis—Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada.
  • Kaechong Lee
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Arne Luz
    A. Luz, Institute of Pathology, GSF München, D 85758 Neuherberg, Germany.
  • Andrea Vortkamp
    A. Vortkamp, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Alison Pirro
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Marcel Karperien
    M. Karperien and L. H. K. Defize, Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands.
  • Libert H. K. Defize
    M. Karperien and L. H. K. Defize, Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands.
  • Chrystal Ho
    C. Ho, Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Richard C. Mulligan
    R. C. Mulligan, Whitehead Institute for Biomedical Research, Cambridge, MA 02142, and Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Abdul-Badi Abou-Samra
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Harald Jüppner
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Gino V. Segre
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Henry M. Kronenberg
    B. Lanske, K. Lee, A. Pirro, A.-B. Abou-Samra, H. Jüppner, G. V. Segre, H. M. Kronenberg, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

抄録

<jats:p>The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, in turn, is likely to activate more than one receptor. The functions of the PTH/PTHrP receptor were investigated by deletion of the murine gene by homologous recombination. Most PTH/PTHrP receptor (−/−) mutant mice died in mid-gestation, a phenotype not observed in PTHrP (−/−) mice, perhaps because of the effects of maternal PTHrP. Mice that survived exhibited accelerated differentiation of chondrocytes in bone, and their bones, grown in explant culture, were resistant to the effects of PTHrP and Sonic hedgehog. These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.</jats:p>

収録刊行物

  • Science

    Science 273 (5275), 663-666, 1996-08-02

    American Association for the Advancement of Science (AAAS)

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