TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

DOI Web Site 被引用文献52件
  • Cun-Yu Wang
    C.-Y. Wang, Curriculum in Genetics and Molecular Biology and Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
  • Marty W. Mayo
    M. W. Mayo, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
  • Albert S. Baldwin
    A. S. Baldwin Jr., Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biology, University of North Carolina, Chapel Hill, NC 27599-7295.

抄録

<jats:p>Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-κB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-κB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-κB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-κB, and have potential for improvement of the efficacy of cancer therapies.</jats:p>

収録刊行物

  • Science

    Science 274 (5288), 784-787, 1996-11

    American Association for the Advancement of Science (AAAS)

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