The N-end rule: functions, mysteries, uses.

• A Varshavsky

  Division of Biology, California Institute of Technology, Pasadena 91125, USA. [e-mail]

抄録

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 93 (22), 12142-12149, 1996-10-29

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360011146021157760
• NII論文ID: 80009344172
• DOI: 10.1073/pnas.93.22.12142
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.93.22.12142
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