マウス運動神経末端における伝達物質遊離に対する塩化第一スズおよび塩化第二スズの作用

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  • Comparison between Effects of Stannous Chloride and Stannic Chloride on the Transmitter Release from Mouse Motor Nerve Terminals

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Stannous chloride (SnCl_2) is thought to facilitate the transmitter release from the motor nerve terminals. Stannous ions tend to become oxidized to stannic ions (Sn^<4+>) in the presence of water and oxygen. Therefore, the results seen with SnCl_2 until now might reflect the properties of Sn^<4+>. In the present study, to ascertain whether SnCl_2 facilitates the transmitter release from mouse motor nerve terminals, we compared the effects of stannic chloride (SnCl_4) on the miniature endplate potential (m. e. p. p.) frequency and the quantal content of the endplate potential (e. p. p.) with those of SnCl_2. We statistically analyzed the mean values of the differences of SnCl_2 (30μM) from its control and of SnCl_4 (30μM) from its control. There were significant differences between the two, both in the m. e. p. p. frequency and in the quantal content. The results obtained demonstrate that the actions of Sn^<4+> are not involved in the effects shown by SnCl_2. We conclude that SnCl_2 facilitates the transmitter release from mouse motor nerve terminals.

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  • 松本歯学

    松本歯学 23 (1), 10-13, 1997-04-30

    松本歯科大学学会

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