Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria

DOI Web Site 被引用文献19件
  • Sophie Kernéis
    Swiss Institute for Experimental Cancer Research, and Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges-Lausanne, Switzerland.
  • Anna Bogdanova
    Swiss Institute for Experimental Cancer Research, and Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges-Lausanne, Switzerland.
  • Jean-Pierre Kraehenbuhl
    Swiss Institute for Experimental Cancer Research, and Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges-Lausanne, Switzerland.
  • Eric Pringault
    Swiss Institute for Experimental Cancer Research, and Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges-Lausanne, Switzerland.

抄録

<jats:p> The epithelium that lines the gut is impermeable to macromolecules and microorganisms, except in Peyer's patches (PPs), where the lymphoid follicle-associated epithelium (FAE) contains M cells that transport antigens and microorganisms. A cultured system that reproduces the main characteristics of FAE and M cells was established by cultivation of PP lymphocytes with the differentiated human intestinal cell line Caco-2. Lymphocytes settled into the epithelial monolayer, inducing reorganization of the brush border and a temperature-dependent transport of particles and <jats:italic>Vibrio cholerae</jats:italic> . This model system could prove useful for intestinal physiology, vaccine research, and drug delivery studies. </jats:p>

収録刊行物

  • Science

    Science 277 (5328), 949-952, 1997-08-15

    American Association for the Advancement of Science (AAAS)

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