Typing of urinary JC virus DNA offers a novel means of tracing human migrations

DOI Web Site 被引用文献17件
  • Chie Sugimoto
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Tadaichi Kitamura
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Jing Guo
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Mohammed N. Al-Ahdal
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Sergei N. Shchelkunov
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Berta Otova
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Paul Ondrejka
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Jean-Yves Chollet
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Sayda El-Safi
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Mohamed Ettayebi
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Gérard Grésenguet
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Tanil Kocagöz
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Sanong Chaiyarasamee
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Kyaw Zin Thant
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Soe Thein
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Kyaw Moe
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Nobuyoshi Kobayashi
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Fumiaki Taguchi
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...
  • Yoshiaki Yogo
    Department of Viral Infection, the Institute of Medical Science, and Department of Urology, Branch Hospital, Faculty of Medicine, the University of Tokyo, Tokyo, Japan; Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia; Department of Biology, Charles University, 1st Faculty of Medicine, Prague,...

抄録

<jats:p>Although polyomavirus JC (JCV) is the proven pathogen of progressive multifocal leukoencephalopathy, the fatal demyelinating disease, this virus is ubiquitous as a usually harmless symbiote among human beings. JCV propagates in the adult kidney and excretes its progeny in urine, from which JCV DNA can readily be recovered. The main mode of transmission of JCV is from parents to children through long cohabitation. In this study, we collected a substantial number of urine samples from native inhabitants of 34 countries in Europe, Africa, and Asia. A 610-bp segment of JCV DNA was amplified from each urine sample, and its DNA sequence was determined. A worldwide phylogenetic tree subsequently constructed revealed the presence of nine subtypes including minor ones. Five subtypes (EU, Af2, B1, SC, and CY) occupied rather large territories that overlapped with each other at their boundaries. The entire Europe, northern Africa, and western Asia were the domain of EU, whereas the domain of Af2 included nearly all of Africa and southwestern Asia all the way to the northeastern edge of India. Partially overlapping domains in Asia were occupied by subtypes B1, SC, and CY. Of particular interest was the recovery of JCV subtypes in a pocket or pockets that were separated by great geographic distances from the main domains of those subtypes. Certain of these pockets can readily be explained by recent migrations of human populations carrying these subtypes. Overall, it appears that JCV genotyping promises to reveal previously unknown human migration routes: ancient as well as recent.</jats:p>

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