25-Hydroxyvitamin D <sub>3</sub> 1α-Hydroxylase and Vitamin D Synthesis

DOI Web Site 被引用文献44件
  • Ken-ichi Takeyama
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.
  • Sachiko Kitanaka
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.
  • Takashi Sato
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.
  • Masato Kobori
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.
  • Junn Yanagisawa
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.
  • Shigeaki Kato
    K. Takeyama, S. Kitanaka, T. Sato, J. Yanagisawa, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan.

抄録

<jats:p> Renal 25–hydroxyvitamin D <jats:sub>3</jats:sub> 1α-hydroxylase [1α(OH)ase] catalyzes metabolic activation of 25–hydroxyvitamin D <jats:sub>3</jats:sub> into 1α,25–dihydroxyvitamin D <jats:sub>3</jats:sub> [1α,25(OH) <jats:sub>2</jats:sub> D <jats:sub>3</jats:sub> ], an active form of vitamin D, and is inhibited by 1α,25(OH) <jats:sub>2</jats:sub> D <jats:sub>3</jats:sub> . 1α(OH)ase, which was cloned from the kidney of mice lacking the vitamin D receptor (VDR <jats:sup>−</jats:sup> <jats:sup>/</jats:sup> <jats:sup>−</jats:sup> mice), is a member of the P450 family of enzymes (P450 <jats:sub>VD1</jats:sub> <jats:sub>α</jats:sub> ). Expression of 1α(OH)ase was suppressed by 1α,25(OH) <jats:sub>2</jats:sub> D <jats:sub>3</jats:sub> in VDR <jats:sup>+/+</jats:sup> and VDR <jats:sup>+/</jats:sup> <jats:sup>−</jats:sup> mice but not in VDR <jats:sup>−</jats:sup> <jats:sup>/</jats:sup> <jats:sup>−</jats:sup> mice. These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1α(OH)ase through liganded VDR. </jats:p>

収録刊行物

  • Science

    Science 277 (5333), 1827-1830, 1997-09-19

    American Association for the Advancement of Science (AAAS)

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