Requirement for V
            <sub>α</sub>
            14 NKT Cells in IL-12-Mediated Rejection of Tumors

Junqing Cui, Tahiro Shin, Tetsu Kawano, Hiroshi Sato, Eisuke Kondo, Isao Toura, Yoshikatsu Kaneko, Haruhiko Koseki, Masamoto Kanno, Masaru Taniguchi

doi:10.1126/science.278.5343.1623

Requirement for V <sub>α</sub> 14 NKT Cells in IL-12-Mediated Rejection of Tumors

DOI Web Site 被引用文献92件

Junqing Cui

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Tahiro Shin

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Tetsu Kawano

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Hiroshi Sato

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Eisuke Kondo

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Isao Toura

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Yoshikatsu Kaneko

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Haruhiko Koseki

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Masamoto Kanno

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Masaru Taniguchi

Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.

抄録

<jats:p> A lymphocyte subpopulation, the V <jats:sub>α</jats:sub> 14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the V <jats:sub>α</jats:sub> 14 and J <jats:sub>α</jats:sub> 281 gene segments. Mice with a deletion of the J <jats:sub>α</jats:sub> 281 gene segment were found to exclusively lack this subpopulation. The V <jats:sub>α</jats:sub> 14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, V <jats:sub>α</jats:sub> 14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12. </jats:p>