Extraocular Circadian Phototransduction in Humans

DOI Web Site 被引用文献8件
  • Scott S. Campbell
    Laboratory of Human Chronobiology, Department of Psychiatry, Cornell University Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA.
  • Patricia J. Murphy
    Laboratory of Human Chronobiology, Department of Psychiatry, Cornell University Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA.

抄録

<jats:p>Physiological and behavioral rhythms are governed by an endogenous circadian clock. The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee). A systematic relation was found between the timing of the light pulse and the magnitude and direction of phase shifts, resulting in the generation of a phase response curve. These findings challenge the belief that mammals are incapable of extraretinal circadian phototransduction and have implications for the development of more effective treatments for sleep and circadian rhythm disorders.</jats:p>

収録刊行物

  • Science

    Science 279 (5349), 396-399, 1998-01-16

    American Association for the Advancement of Science (AAAS)

被引用文献 (8)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ