Autophosphorylation at Thr <sup>286</sup> of the α Calcium-Calmodulin Kinase II in LTP and Learning

DOI Web Site 被引用文献50件
  • Karl Peter Giese
    K. P. Giese, N. B. Fedorov, A. J. Silva, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Nikolai B. Fedorov
    K. P. Giese, N. B. Fedorov, A. J. Silva, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Robert K. Filipkowski
    K. P. Giese, N. B. Fedorov, A. J. Silva, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Alcino J. Silva
    K. P. Giese, N. B. Fedorov, A. J. Silva, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

抄録

<jats:p> The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–dependent activity, CaMKII can undergo autophosphorylation, resulting in CaM-independent activity. A point mutation was introduced into the αCaMKII gene that blocked the autophosphorylation of threonine at position 286 (Thr <jats:sup>286</jats:sup> ) of this kinase without affecting its CaM-dependent activity. The mutant mice had no <jats:italic>N</jats:italic> -methyl- <jats:sc>d</jats:sc> -aspartate receptor–dependent LTP in the hippocampal CA1 area and showed no spatial learning in the Morris water maze. Thus, the autophosphorylation of αCaMKII at Thr <jats:sup>286</jats:sup> appears to be required for LTP and learning. </jats:p>

収録刊行物

  • Science

    Science 279 (5352), 870-873, 1998-02-06

    American Association for the Advancement of Science (AAAS)

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