塩化第二スズによるマウス神経筋伝達の抑制

書誌事項

タイトル別名

• Inhibition of Mouse Neuromuscular Transmission by Stannic Chloride

抄録

The present study was conducted to determine whether stannic chloride (SnCl_4) at concentrations above 50цM inhibits or facilitates neuromuscular transmission. SnCl_4 decreased the amplitude of the endplate potential (e.p.p.) concentration-dependently in a concentration range from 0.05 to 0.5mM. Not only SnCl_4 (0.5mM) but also tartaric acid (TA, 0.5mM), a solvent for 0.5 mM SnCl_4, decreased the e.p.p.. The action of SnCl_4 was stronger than that of TA. Both SnCl_4 (0.5mM) and TA (0.5mM) decreased the quantal content of the e.p.p., and the action of the former was significantly stronger than that of the latter. SnCl_4 (0.5mM) raised the frequency of the miniature endplate potential (m.e.p.p.), whereas TA (0.5mM) reduced it. SnCl_4 (0.5mM) decreased the m.e.p.p. amplitude as did TA (0.5mM). The results obtained show that SnCl_4 inhibits neuromuscular transmission by decreasing the volume of the transmitters released by nerve impulses.

収録刊行物

• 松本歯学

  松本歯学 24 (1), 46-51, 1998-04-30

  松本歯科大学学会

キーワード

• stannic chloride
• tartaric acid
• neuromuscular transmission
• mouse

詳細情報

• CRID: 1570009751801377536
• NII論文ID: 80010374660
• NII書誌ID: AN00232590
• ISSN: 03851613
• Web Site: http://id.nii.ac.jp/1070/00000740/
• 本文言語コード: en
• データソース種別:
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