Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

DOI Web Site 被引用文献70件
  • Avidan U. Neumann
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • Nancy P. Lam
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • Harel Dahari
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • David R. Gretch
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • Thelma E. Wiley
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • Thomas J. Layden
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...
  • Alan S. Perelson
    A. U. Neumann, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel, and Santa Fe Institute, Santa Fe, NM 87501, USA. N. P. Lam, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA. H. Dahari, Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. D. R. Gretch, Hepatitis Laboratory, University of Washington, Seattle, WA 98144, USA. T. E. Wiley and T. J. Layden, Section of Digestive and Liver Diseases, Department of Medicine,...

抄録

<jats:p> To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-α-2b (IFN), viral decline in 23 patients during therapy was analyzed with a mathematical model. The analysis indicates that the major initial effect of IFN is to block virion production or release, with blocking efficacies of 81, 95, and 96% for daily doses of 5, 10, and 15 million international units, respectively. The estimated virion half-life ( <jats:italic>t</jats:italic> <jats:sub>1/2</jats:sub> ) was, on average, 2.7 hours, with pretreatment production and clearance of 10 <jats:sup>12</jats:sup> virions per day. The estimated infected cell death rate exhibited large interpatient variation (corresponding <jats:italic>t</jats:italic> <jats:sub>1/2</jats:sub> = 1.7 to 70 days), was inversely correlated with baseline viral load, and was positively correlated with alanine aminotransferase levels. Fast death rates were predictive of virus being undetectable by polymerase chain reaction at 3 months. These findings show that infection with hepatitis C virus is highly dynamic and that early monitoring of viral load can help guide therapy. </jats:p>

収録刊行物

  • Science

    Science 282 (5386), 103-107, 1998-10-02

    American Association for the Advancement of Science (AAAS)

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