Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

DOI Web Site 被引用文献34件
  • Daniel J. Dumont
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Lotta Jussila
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Jussi Taipale
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Athina Lymboussaki
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Tuija Mustonen
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Katri Pajusola
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Martin Breitman
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Kari Alitalo
    D. J. Dumont, Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1. L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, PL 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. M. Breitman, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

抄録

<jats:p>Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. Here it is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.</jats:p>

収録刊行物

  • Science

    Science 282 (5390), 946-949, 1998-10-30

    American Association for the Advancement of Science (AAAS)

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