The Transcriptional Program in the Response of Human Fibroblasts to Serum

  • Vishwanath R. Iyer
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Michael B. Eisen
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Douglas T. Ross
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Greg Schuler
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Troy Moore
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Jeffrey C. F. Lee
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Jeffrey M. Trent
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Louis M. Staudt
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • James Hudson
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Mark S. Boguski
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Deval Lashkari
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Dari Shalon
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • David Botstein
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....
  • Patrick O. Brown
    V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M....

抄録

<jats:p>The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.</jats:p>

収録刊行物

  • Science

    Science 283 (5398), 83-87, 1999-01

    American Association for the Advancement of Science (AAAS)

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