<i>Xid</i> -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

• Harumi Suzuki

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Yasuo Terauchi

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Mari Fujiwara

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Shinichi Aizawa

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Yoshio Yazaki

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Takashi Kadowaki

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

• Shigeo Koyasu

  H. Suzuki, M. Fujiwara, S. Koyasu, Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Y. Terauchi, Y. Yazaki, T. Kadowaki, Department of Internal Medicine, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. S. Aizawa, Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860, Japan.

Abstract

Mice with a targeted gene disruption of p85α, a regulatory subunit of phosphoinositide 3-kinase, had impaired B cell development at the pro–B cell stage, reduced numbers of mature B cells and peritoneal CD5 + Ly-1 B cells, reduced B cell proliferative responses, and no T cell–independent antibody production. These phenotypes are nearly identical to those of Btk −/− or xid (X-linked immunodeficiency) mice. These results provide evidence that p85α is functionally linked to the Btk pathway in antigen receptor–mediated signal transduction and is pivotal in B cell development and functions.

Journal

• Science

  Science 283 (5400), 390-392, 1999-01-15

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1361699994290160384
• NII Article ID: 80010876082
• DOI: 10.1126/science.283.5400.390
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.283.5400.390
• Data Source:
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