OLFACTORY NEUROBLASTOMA; A REPORT OF TWO CASES

DOI 2 Citations
  • Nakagawa Akiko
    筑波大学医学研究科
  • Senarita Masamitsu
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Takahashi Kazuhiko
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Okubo Hideki
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Wada Tetsuro
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Ito Zennya
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Hara Akira
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Kusakari Jun
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Tsukuba
  • Tsuboi Kohji
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
  • Tomono Yuji
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
  • Nose Tadao
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
  • Endo Takashi
    Department of Plastic Surgery, Institute of Clinical Medicine, University of Tsukuba
  • Nakayama Yoshio
    Department of Plastic Surgery, Institute of Clinical Medicine, University of Tsukuba
  • Inadome Yukinori
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba
  • Shimokama Tatsuro
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba

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Other Title
  • 嗅神経芽細胞腫の2例

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Abstract

We report two cases of olfactory neuroblastoma experienced in the past ten years. Patients were 27 and 68 year-old men, whose chief complaints were unilateral nasal obstruction and epistaxis. Diagnosis was made by immunohistochemical examination in addition to light microscopic findings. The extention of the tumor was examined by CT scan and MRI the latter of which was very useful to assess the intracranial involvement.<BR>Both patients were treated with preoperative radiotherapy and anterior skull base surgery. The case 1 suffered from postoperative extradural abscess, which was needed another skull base reconstructive operation. He also developed cervical lymph nodes metastasis 42 months later and underwent neck disection several times. In the other case, the postoperative course has been uneventful and clinical sign suggesting local reccurence or metastasis is not found during the observation period of 39 months.

Journal

  • JIBI INKOKA TEMBO

    JIBI INKOKA TEMBO 42 (Supplement1), 52-57, 1999

    Society of Oto-rhino-laryngology Tokyo

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