Bone Marrow as a Potential Source of Hepatic Oval Cells

• B. E. Petersen

  Department of Pathology,

• W. C. Bowen

  Department of Pathology,

• K. D. Patrene

  Department of Radiation Oncology,

• W. M. Mars

  Department of Pathology,

• A. K. Sullivan

  Department of Hematology/Oncology, McGill University, Quebec H3A 2T5, Canada.

• N. Murase

  Division of Transplant Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

• S. S. Boggs

  Department of Radiation Oncology,

• J. S. Greenberger

  Department of Radiation Oncology,

• J. P. Goff

  Department of Radiation Oncology,

抄録

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

収録刊行物

• Science

  Science 284 (5417), 1168-1170, 1999-05-14

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360855569554829696
• NII論文ID: 80011096559
• DOI: 10.1126/science.284.5417.1168
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.284.5417.1168
• データソース種別:
  • Crossref
  • CiNii Articles