<i>Math1</i> : An Essential Gene for the Generation of Inner Ear Hair Cells

• Nessan A. Bermingham

  Howard Hughes Medical Institute,

• Bassem A. Hassan

  Howard Hughes Medical Institute,

• Steven D. Price

  Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.

• Melissa A. Vollrath

  Division of Neuroscience,

• Nissim Ben-Arie

  Department of Molecular and Human Genetics,

• Ruth Anne Eatock

  Division of Neuroscience,

• Hugo J. Bellen

  Howard Hughes Medical Institute,

• Anna Lysakowski

  Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.

• Huda Y. Zoghbi

  Howard Hughes Medical Institute,

抄録

The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1 , a mouse homolog of the Drosophila proneural gene atonal , is expressed in inner ear sensory epithelia. Embryonic Math1 -null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.

収録刊行物

• Science

  Science 284 (5421), 1837-1841, 1999-06-11

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363670319530230400
• NII論文ID: 80011146205
• DOI: 10.1126/science.284.5421.1837
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.284.5421.1837
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