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- Nessan A. Bermingham
- Howard Hughes Medical Institute,
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- Bassem A. Hassan
- Howard Hughes Medical Institute,
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- Steven D. Price
- Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
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- Melissa A. Vollrath
- Division of Neuroscience,
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- Nissim Ben-Arie
- Department of Molecular and Human Genetics,
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- Ruth Anne Eatock
- Division of Neuroscience,
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- Hugo J. Bellen
- Howard Hughes Medical Institute,
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- Anna Lysakowski
- Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
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- Huda Y. Zoghbi
- Howard Hughes Medical Institute,
抄録
<jats:p> The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. <jats:italic>Math1</jats:italic> , a mouse homolog of the <jats:italic>Drosophila</jats:italic> proneural gene <jats:italic>atonal</jats:italic> , is expressed in inner ear sensory epithelia. Embryonic <jats:italic>Math1</jats:italic> -null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells. </jats:p>
収録刊行物
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- Science
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Science 284 (5421), 1837-1841, 1999-06-11
American Association for the Advancement of Science (AAAS)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1363670319530230400
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- NII論文ID
- 80011146205
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- ISSN
- 10959203
- 00368075
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- データソース種別
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- Crossref
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