Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

• Cheol-Koo Lee

  Environmental Toxicology Center,

• Roger G. Klopp

  Institute on Aging,

• Richard Weindruch

  Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA.

• Tomas A. Prolla

  Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.

抄録

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

収録刊行物

• Science

  Science 285 (5432), 1390-1393, 1999-08-27

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363107369170587264
• NII論文ID: 80011300617
• DOI: 10.1126/science.285.5432.1390
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.285.5432.1390
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